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But r (t) r (t)0 (see Example 13. J Trop Paediatr 1996;42:31823. For example, biomedical engineers engaged in the Index Goldman-Hodgkin-Katz (GHK) equation 349, fast 137 slow 134 induced surface charges 511 inhibitor 8 inhomogeneous dielectric medium inner vestibule 128 interfacial polarization 58 intracellular eates 559 Inward rectifier potassium channels 435436 ion atmosphere 485, 486 ion binding sites 52 ion channel modeling (gating) 353 Goldman-Hodgkin-Katz theory 455, 457 gramicidin 4, 8, 11, 12, 16, 17, 19, 333373, 486, 487, 500 gramicidin A 461, 471, 595596, 602604 452 13, 425, 432, -Helix 35 anti-bacterial activity 33 atomic resolution structure channel function 3538, 4964, 521522 conformational polymorphism 3435, 40 conformational preference double-stranded (DS) helix 4546 43, 45 35, 39, 4142, 34, 3839, 4346 50-state model (Rothberg and Magleby) 193195, 199 HA Model 194197, 206 HCA Model 191193 MWC 179182, 186188, 191193 VD-MWC Model 179197 ion channel switch 596, 604, 616 ion charge selectivity 348, 349, 353 ion conduction 595, 606 ion dissociation constant 61, 67 heterodimers fore hybrid channels 47 mini channels 36 single-stranded (SS) helix structural equivalence 46 GsMtx-4, spider venom peptide hair-cell transduction channel Hamiltonian 497 helical screw 97 387 375, 383 4647 4647 helix kink 556 Helmholtz layer hereditary sodium channel diseases hERG channel 572 Hessian matrix 640643 hidden Markov models 623650 high throughput 572 Hill coefficient 176, 180, 183188 hinge-bending hypothesis histidine scanning 101 HMM filter 636637 HMM see hidden Markov models HMM smoothing 638 homologous domains 82 homology 9, 10, 11, 13, 14, 17 homology modelling 546 hydration forces 526 hydration 5, 6, 485, 494, 495, 497 hydrophobic gate 558 hydrophobicity 12, 14, 18 hyperpolarization-activated chloride current IFM motif 228, 231 immunosensing device impedance spectroscopy implicit water 509 inactivation 8, 119, 129 ion free energy ion permeation ion selectivity 451, 45 552 254, 255, ratds, 257, 433, 435, 654 3839 488, 489, 490, 491, 498, 500 233234 436 ion-dipole interactions 58 ionic species 451 ion-ion interactions 62 ion-peptide backbone interactions 67 IP3 receptors 246, 247, 248, 249, 250, 251, 557 252 irreversible gating 313 isothiocyanate 411 I-V curves (characteristics) Rwtes inequality 628 jump Markov linear system 595 595, 601, 612 ratss K channel (see also potassium channel) 82, 119170 K secretion 438 Kalman filter 633, 636, 646 KCa1.
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